Neurotoxicity of Opioids: Are We Responding?. by Jose Pereira, M.D. With the increased utilization of opioid analgesics, has come an increased detection of "newer" adverse effects.
Nonmalignant Chronic Pain: Taking the Time to Treat from American Family Physician, May 1, 2009.
Chronic Pain: 1. A New Disease? by DANIEL BROOKOFF, University of Tennessee. "Chronic pain continues to be perceived as a characterologic disorder rather than a serious, potentially fatal, medical disease. The general lack of understanding of how persistent pain becomes magnified and ingrained prevents many patients from receiving the level of care that they need to regain control of their lives and resume normal activities."
Chronic Pain: 2. The Case for Opioids. by DANIEL BROOKOFF, University of Tennessee. "Opioid medications allow us to treat chronic pain as aggressively as we would any pathogen, but we must first overcome ingrained misconceptions about patients' motivations for seeking treatment and about the addictive properties of the drugs. With controlled use, the newer sustained-release formulations give real hope for safe and sustained pain relief."
Update: cancer pain management. by Eric W. Anderson, M.D. Focuses on four areas of controversy and research: patients’ expectations about pain management, the use of newer opioid formulations, methadone hydrochloride’s reemergence as an analgesic, and palliative care for the patient who is actively dying.
Those Nasty Opioid Conversions: How To Do Them. Basic Procedure to convert from "old" to "new" opioid regimen.
Neuropathic Pain: New Insights, New Interventions Part 2. by Gary J. Bennett, Professor of Neurology and Director of Pain Research, Allegheny University of the Health Sciences, Philadelphia. "The past decade has seen great progress in understanding its causes and in finding new drugs that promise great benefit. An early outcome of the research has been the observation that the new drugs do not blunt normal pain sensation--a pattern beginning to find explanation through the realization that neural pain circuits rewire themselves, both anatomically and biochemically, after nerve injury."